Amphetamine is understood to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit many P450 isozymes as well as other enzymes hasn't been adequately elucidated. In vitro experiments with human microsomes show minimal inhibition of CYP2D6 by amphetamine and small inhibition of CYP1A2, 2D6, and 3A4 by a num